Design and synthesis of NOVEL denrimeric structures for applications in various biomedical and biological sciences. The idea is to design structures as building blocks that can impart specific function to materials.
Projects involve organic synthesis of dendrons, dendrimer and multi-arm polymers that can be functionalized for particular function such as drug delivery or disease diagnostics. Techniques/tools such as organic synthesis, NMR characterizations, GPC, MALDI mass spectroscopy, drug and protein conjugation are employed.
Sumer Bolu, Burcu; Manavoglu Gecici, Ece; Sanyal, Rana “Combretastatin A-4 Conjugated Anti-Angiogenic Micellar Drug Delivery Systems Using Dendron-Polymer Conjugates” ACS Molecular Pharmaceutics, 2016, 13(5), 1482-1490.
Baradel, N.; Gok, O.; Zamfir, M.; Sanyal, A.; Lutz, J.-F. “Sequence-controlled Polymerizations Using Dendritic Macromonomers: Precise Chain-Positioning of Bulky Functional Clusters” Chemical Communications 2013, 49, 7280-7282 (Cover Article).
Kose M. M., Onbulak, S., Yilmaz, I. I., Sanyal, A. "Orthogonally ‘Clickable’ Biodegradable Dendrons" Macromolecules, 2011, 44, 2707-2714.
Kose, M. M.; Yesilbag, G.; Sanyal A. "Segment Block Dendrimers via Diels- Alder Cycloaddition" Organic Letters 2008, 2353 -2356.