Drug Modification
Focus: 

Synthesis of novel derivatives of anti-cancer drugs via organic synthesis.

Method: 

Organic synthesis to design drug derivatives that can be readily incorporated in drug delivery systems. Synthesis, purification and characterization via variety of analytical methods. Testing of activity of drugs and their derivatives via cell bio-assay.

Publications: 
  • Yuan, C. C.; Yang, K.; Vanderplas, S.; Riahi, B.;Potashman, M.; Patel, V. F.; Nomak, R.; Li, A.; Huang, Q.; Harmange, J.-C.;Askew, B. C., Jr. "Preparation of substituted arylamine derivatives,particularly 2-aminonicotinamides, as antitumor agents." PCT Int. Appl.(2006), WO 2006012374 A1.
  • Askew, B. C.; Aya, T.; Biswas, K.; Cai, G.; Chen, J.J.; Han, N.; Liu, Q.; Nguyen, T.; Nishimura, N.; Nomak, R.; Peterkin, T.; Qian,W.; Yang, K.; Yuan, C. C.; Zhu, J.; D' Amico, D. C.; Human, J. B.; Huang, Q."Preparation of 1,2,3,4-tetrahydropyrazin-2-yl acetamides as bradykinin B1receptor antagonists for treating pain and diseases such asinflammation-mediated diseases." U.S. Pat. Appl. Publ. (2006), US2006025400 A1.
  • Tegley, C.; Adams, J. A.; Askew, B. C., Jr.; Croghan,M.; Elbaum, D.; Germain, J.; Habgood, G. J.; Harried, S.; Li, A.; Nishimura,N.; Nomak, R.; Tasker, A.; Yang, K. “Preparation of substituted2,3-dihydro-1H-isoindol-1-one derivatives as VEGF modulators and methods of useagainst cancer and other disorders.” PCT Int. Appl. Publ. (2005), WO 2005021532A1.
  • Chen, J. J.; Askew, B. C.; Biswas,K.; Chau, J. N.; D'Amico, D. C.; Harried, S.; Nguyen, T.; Qian, W.; Zhu, J.;Fotsch, C. H.; Li, A.; Liu, Q.; Nishimura, N.; Peterkin, T.; Riahi, B.; Yuan,C. C.; Han, N.; Nomak, R.; Yang, K. “Preparation ofarylsufonyloxopiperazinylacetamides for treatment of inflammation and pain.”U.S. Pat. Appl. Publ. (2005), US 2005014749 A1.
  • Groneberg, R. D.; Askew, B.;D'Amico, D.; Zhan, J.; Toro, A.; Suzuki, H.; Mareska, D. A.; Han, N.; Fotsch,C. H.; Liu, Q.; Riahi, B.; Yang, K.; Li, A.; Yuan, C.; Biswas, K.; Harried, S.;Nguyen, T.; Qian, W.; Chen, J. J.; Nomak, R. “Preparation ofN-bicyclyl-3-[[(hetero)arylsulfonyl]amino]-3-(hetero)arylpropionamides asbradykinin receptor modulators for treatment of pain, inflammation, and otherconditions.” PCT Int. Appl. (2004), WO 2004092116 A1.
  • Groneberg, R. D.; Zhan, J.; Askew, B.; D'Amico, D.;Han, N.; Fotsch, C. H.; Liu, Q.; Riahi, B.; Zhu, J.; Yang, K.; Chen, J. J.;Nomak, R. “Preparation of cyclic amine derivatives as bradykinin antagonistsand their use in the treatment of pain and inflammation.” PCT Int. Appl.(2004), WO 2004092164 A1.
  • Askew, B. C.; De Morin, F. F.;Hague, A.; Laber, E.; Li, A.; Liu, G.; Lopez, P.; Nomak, R.; Santora, V.;Tegley, C.; Yang, K. “Preparation of N-thiazolyl-N'-pyridyl ureas as antitumoragents.” U.S. Pat. Appl. Publ. (2004), US 0039029 A1.
  • Patel, V. F.; Askew, B.; Booker, S.;Chen, G.; Dipietro, L. V.; Germain, J.; Habgood, G. J.; Huang, Q.; Kim, T.; Li,A.; Nishimura, N.; Nomak, R.; Riahi, B.; Yuan, C. C.; Elbaum, D. “Preparationof amino heteroaryl amides for use in pharmaceutical compositions for thetreatment of angiogenesis mediated diseases such as cancer.” U.S. Pat. Appl.Publ. (2003) US 2003203922 A1.
  • Askew, B.C.; Adams, J.; Booker, S.;Chen, G.; Dipietro, L. V.; Elbaum, D.; Germain, J.; Geuns-Meyer, S. D.;Habgood, G. J.; Handley, M.; Huang, Q.; Kim, T.; Li, A.; Nishimura, N.; Nomak,R.; Patel, V. F.; Riahi, B.; Kim, J. L.; Xi, N.; Yang, K.; Yuan, C. C.“Preparation of 2-aminopyridine-3-carboxamides as remedies for angiogenesismediated diseases.” U.S. Pat. Appl. Publ. (2003), US 2003225106 A1.
  • Askew, B. C.; De Morin, F. F.; Hague, A.; Laber, E.;Li, A.; Liu, G.; Lopez, P.; Nomak, R.; Santora, V.; Tegley, C.; Yang, K.“Preparation of N-thiazolyl-N'-pyridyl ureas as antitumor agents.” U.S. Pat.Appl. Publ. (2003), US 6,645,990.
  • Askew, B. C.; De Morin, F. F.;Hague, A.; Laber, E.; Li, A.; Liu, G.; Lopez, P.; Nomak, R.; Santora, V.;Tegley, C.; Yang, K. “Preparation of N-thiazolyl-N'-pyridyl ureas as antitumoragents.” U.S. Pat. Appl. Publ. (2002), US 2002193405 A1.